Hemorrhagic Herpes Simplex Virus Type 1 Nephritis: An Unusual Cause of Acute Allograft Dysfunction

Am J Transplant. 2017 Jan;17(1):287-291. doi: 10.1111/ajt.14022. Epub 2016 Sep 14.

Abstract

Interstitial nephritis due to viruses is well-described after solid organ transplantation. Viruses implicated include cytomegalovirus; BK polyomavirus; Epstein-Barr virus; and, less commonly, adenovirus. We describe a rare case of hemorrhagic allograft nephritis due to herpes simplex virus type 1 at 10 days after living donor kidney transplantation. The patient had a favorable outcome with intravenous acyclovir and reduction of immunosuppression.

Keywords: clinical research/practice; donors and donation; infection and infectious agents; infectious disease; kidney disease: infectious; kidney transplantation/nephrology; kidney transplantation: living donor; viral.

Publication types

  • Case Reports

MeSH terms

  • Acyclovir / therapeutic use
  • Allografts
  • Antiviral Agents / therapeutic use
  • Glomerular Filtration Rate
  • Graft Rejection / etiology*
  • Graft Rejection / pathology
  • Graft Survival
  • Hemorrhage / drug therapy
  • Hemorrhage / virology*
  • Herpes Simplex / complications*
  • Herpesvirus 1, Human / pathogenicity*
  • Humans
  • Immunosuppression
  • Kidney Failure, Chronic / surgery*
  • Kidney Function Tests
  • Kidney Transplantation / adverse effects*
  • Male
  • Middle Aged
  • Nephritis / drug therapy
  • Nephritis / virology*
  • Prognosis
  • Risk Factors

Substances

  • Antiviral Agents
  • Acyclovir