Evaluation of peri-implant crevicular fluid prostaglandin E 2 levels in augmented extraction sockets by different biomaterials

Acta Odontol Scand. 2016 Oct;74(7):532-538. doi: 10.1080/00016357.2016.1214979. Epub 2016 Aug 22.


Objectives: This study compares peri-implant crevicular fluid (PICF) prostaglandin E2 (PGE2) levels, clinical parameters and implant stability quotient (ISQ) values around implants placed in augmented extraction sockets.

Materials and methods: The sockets (24 in total) were randomly augmented using either EMD or Bio-Oss Collagen. Implant placements were performed after three months of healing. ISQ readings were evaluated at three points: at the time of surgery, at the first month and at the third month. PICF was collected for PGE2 evaluation after the first and the third months of implant surgery.

Results: After the first month, a higher level of PICF PGE2 was observed in the EMD group than in the Bio-Oss Collagen group, and this increase was of statistical significance; however, at the third month there was no statistically significant difference in PICF PGE2 levels between the two groups. For implants placed in EMD sites, ISQ values were statistically higher at the third month than at the first month, while no significant differences in ISQ value were detected between the first and third months in Bio-Oss Collagen sites.

Conclusions: The results of this research suggest that both EMD and Bio-Oss Collagen are effective treatment modalities for stimulating the formation of new bone at extraction sites prior to implant surgery.

Keywords: Extraction sockets; augmentation; peri-implant crevicular fluid; prostoglandin E2.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Alveolar Ridge Augmentation / methods*
  • Biocompatible Materials / therapeutic use*
  • Bone Density / physiology
  • Bone Substitutes / therapeutic use*
  • Collagen / therapeutic use
  • Dental Enamel Proteins / therapeutic use
  • Dental Implantation, Endosseous / methods
  • Dental Implants*
  • Dental Plaque Index
  • Dinoprostone / analysis*
  • Female
  • Follow-Up Studies
  • Gingival Crevicular Fluid / chemistry*
  • Humans
  • Male
  • Middle Aged
  • Minerals / therapeutic use
  • Osteogenesis / physiology
  • Periodontal Index
  • Tooth Socket / surgery*
  • Wound Healing / physiology


  • Bio-Oss
  • Biocompatible Materials
  • Bone Substitutes
  • Dental Enamel Proteins
  • Dental Implants
  • Minerals
  • enamel matrix proteins
  • Collagen
  • Dinoprostone