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. 2016 Aug 18;5(8):73.
doi: 10.3390/jcm5080073.

Physical Activity and Exertional Desaturation Are Associated With Mortality in Idiopathic Pulmonary Fibrosis

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Free PMC article

Physical Activity and Exertional Desaturation Are Associated With Mortality in Idiopathic Pulmonary Fibrosis

Baruch Vainshelboim et al. J Clin Med. .
Free PMC article

Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease that manifests in hypoxemia, inactivity, and poor prognosis. This study aimed to assess the prognostic role of physical activity (PA) and exertional desaturation (ED) with mortality in IPF. At baseline, 34 IPF patients (68 (50-81) years) were interviewed using the International Physical Activity Questionnaire (IPAQ), and SpO₂ was assessed pre to post 6-min walking test (∆SpO₂). Patients were prospectively followed up for 40 months. Receiver operating characteristics curve analysis determined cut-off points associated with mortality, and Cox proportional hazard ratio (HR) were conducted. Thresholds for increased mortality risk in IPF patients were determined as IPAQ ≤ 417 metabolic equivalent task (METS)-min/week, p = 0.004 (HR; 9.7, CI 95% (1.3-71.9), p = 0.027), and ∆SpO₂ ≥ 10%, p = 0.002, (HR; 23.3, CI 95% (1.5-365), p = 0.025). This study demonstrated a significant association of PA and ED with mortality in IPF patients. The findings emphasize the clinical importance of PA and ED assessments to aid in IPF risk stratification, prognosis prediction, and in providing early appropriate treatments, such as pulmonary rehabilitation, PA consultation, oxygen supplementation, and lung transplantation referral. These results underscore that even low levels of PA corresponding to 100-105 min/week were associated with a reduced mortality risk and better survival in IPF.

Keywords: exercise; inactivity; international physical activity questionnaire; interstitial lung disease; pulmonary rehabilitation.

Figures

Figure 1
Figure 1
Kaplan–Meir survival curves and hazard ratio for physical activity threshold in patients with idiopathic pulmonary fibrosis.
Figure 2
Figure 2
Kaplan–Meir survival curves and hazard ratio for exertional desaturation (∆SpO2) threshold in patients with idiopathic pulmonary fibrosis.

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References

    1. Raghu G., Collard H.R., Egan J.J., Martinez F.J., Behr J., Brown K.K., Colby T.V., Cordier J.F., Flaherty K.R., Lasky J.A., et al. An official ATS/ERS/JRS/ALAT statement: Idiopathic pulmonary fibrosis: Evidence-based guidelines for diagnosis and management. Am. J. Respir. Crit. Care Med. 2011;183:788–824. doi: 10.1164/rccm.2009-040GL. - DOI - PMC - PubMed
    1. Olson A.L., Swigris J.J., Lezotte D.C., Norris J.M., Wilson C.G., Brown K.K. Mortality from pulmonary fibrosis increased in the United States from 1992 to 2003. Am. J. Respir. Crit. Care Med. 2007;176:277–284. doi: 10.1164/rccm.200701-044OC. - DOI - PubMed
    1. Meltzer E.B., Noble P.W. Idiopathic pulmonary fibrosis. Orphanet J. Rare Dis. 2008;3:8. doi: 10.1186/1750-1172-3-8. - DOI - PMC - PubMed
    1. Lama V.N., Flaherty K.R., Toews G.B., Colby T.V., Travis W.D., Long Q., Murray S., Kazerooni E.A., Gross B.H., Lynch J.P., 3rd, et al. Prognostic value of desaturation during a 6-min walk test in idiopathic interstitial pneumonia. Am. J. Respir. Crit. Care Med. 2003;168:1084–1090. doi: 10.1164/rccm.200302-219OC. - DOI - PubMed
    1. Swigris J.J., Brown K.K., Make B.J., Wamboldt F.S. Pulmonary rehabilitation in idiopathic pulmonary fibrosis: A call for continued investigation. Respir. Med. 2008;102:1675–1680. doi: 10.1016/j.rmed.2008.08.014. - DOI - PMC - PubMed
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