Renal Denervation Normalizes Arterial Pressure With No Effect on Glucose Metabolism or Renal Inflammation in Obese Hypertensive Mice

Hypertension. 2016 Oct;68(4):929-36. doi: 10.1161/HYPERTENSIONAHA.116.07993. Epub 2016 Aug 22.


Hypertension often occurs in concurrence with obesity and diabetes mellitus, commonly referred to as metabolic syndrome. Renal denervation (RDNx) lowers arterial pressure (AP) and improves glucose metabolism in drug-resistant hypertensive patients with high body mass index. In addition, RDNx has been shown to reduce renal inflammation in the mouse model of angiotensin II hypertension. The present study tested the hypothesis that RDNx reduces AP and renal inflammation and improves glucose metabolism in obesity-induced hypertension. Eight-week-old C57BL/6J mice were fed either a low-fat diet (10 kcal%) or a high-fat diet (45 kcal%) for 10 weeks. Body weight, food intake, fasting blood glucose, and glucose metabolism (glucose tolerance test) were measured. In a parallel study, radiotelemeters were implanted in mice for AP measurement. High fat-fed C57BL/6J mice exhibited an inflammatory and metabolic syndrome phenotype, including increased fat mass, increased AP, and hyperglycemia compared with low-fat diet mice. RDNx, but not Sham surgery, normalized AP in high-fat diet mice (115.8±1.5 mm Hg in sham versus 96.6±6.7 mm Hg in RDNx). RDNx had no significant effect on AP in low-fat diet mice. Also, RDNx had no significant effect on glucose metabolism or renal inflammation as measured by the number of CD8, CD4, and T helper cells or levels of inflammatory cytokines in the kidneys. These results indicate that although renal nerves play a role in obesity-induced hypertension, they do not contribute to impaired glucose metabolism or renal inflammation in this model.

Keywords: T cell; cytokines; glucose; hypertension; metabolic syndrome; renal denervation.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Arterial Pressure / physiology*
  • Autonomic Denervation / methods*
  • Blood Glucose / metabolism
  • Body Weight
  • Cytokines / metabolism
  • Diet, High-Fat
  • Disease Models, Animal
  • Flow Cytometry
  • Hypertension / etiology
  • Hypertension / physiopathology*
  • Immunohistochemistry
  • Kidney / pathology
  • Kidney / surgery*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Obese
  • Nephritis / pathology*
  • Nephritis / physiopathology
  • Obesity / complications
  • Random Allocation
  • Sensitivity and Specificity


  • Blood Glucose
  • Cytokines