Successful Treatment of Bloodstream Infection Due to Metallo-β-Lactamase-Producing Stenotrophomonas maltophilia in a Renal Transplant Patient

Antimicrob Agents Chemother. 2016 Aug 22;60(9):5130-4. doi: 10.1128/AAC.00264-16. Print 2016 Sep.

Abstract

Stenotrophomonas maltophilia is an emerging multidrug-resistant (MDR) opportunistic pathogen for which new antibiotic options are urgently needed. We report our clinical experience treating a 19-year-old renal transplant recipient who developed prolonged bacteremia due to metallo-β-lactamase-producing S. maltophilia refractory to conventional treatment. The infection recurred despite a prolonged course of colistimethate sodium (colistin) but resolved with the use of a novel drug combination with clinical efficacy against the patient's S. maltophilia isolate.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Azabicyclo Compounds / therapeutic use*
  • Aztreonam / therapeutic use*
  • Bacteremia / drug therapy*
  • Bacteremia / microbiology
  • Bacteremia / pathology
  • Ceftazidime / therapeutic use*
  • Colistin / therapeutic use
  • Drug Combinations
  • Drug Resistance, Multiple, Bacterial
  • Drug Substitution
  • Gene Expression
  • Gram-Negative Bacterial Infections / drug therapy*
  • Gram-Negative Bacterial Infections / microbiology
  • Gram-Negative Bacterial Infections / pathology
  • Humans
  • Kidney Transplantation*
  • Male
  • Polycystic Kidney Diseases / pathology
  • Polycystic Kidney Diseases / surgery
  • Stenotrophomonas maltophilia / drug effects*
  • Stenotrophomonas maltophilia / genetics
  • Stenotrophomonas maltophilia / growth & development
  • Stenotrophomonas maltophilia / pathogenicity
  • Young Adult
  • beta-Lactamases / genetics
  • beta-Lactamases / metabolism

Substances

  • Anti-Bacterial Agents
  • Azabicyclo Compounds
  • Drug Combinations
  • avibactam, ceftazidime drug combination
  • Ceftazidime
  • beta-Lactamases
  • Aztreonam
  • Colistin