Protective effects of a blueberry extract in acute inflammation and collagen-induced arthritis in the rat

Biomed Pharmacother. 2016 Oct;83:1191-1202. doi: 10.1016/j.biopha.2016.08.040. Epub 2016 Aug 20.


Here we investigated the anti-inflammatory effect of a blueberry extract in the carrageenan-induced paw edema model and collagen-induced arthritis model, both in rats. Along with the chemical characterization of the phenolic content of the fruits and extract, the antioxidant potential of the extract, the cellular antioxidant activity and the effects over neutrophils' oxidative burst, were studied in order to provide a mechanistic insight for the anti-inflammatory effects observed. The extract significantly inhibited paw edema formation in an acute model the rat. Our results also demonstrate that the standardized extract had pharmacological activity when administered orally in the collagen-induced arthritis model in the rat and was able to significantly reduce the development of clinical signs of arthritis and the degree of bone resorption, soft tissue swelling and osteophyte formation, consequently improving articular function in treated animals.

Keywords: Anti-inflammatory; Blueberry fruit; Collagen induced arthritis; Oxidative burst; Vaccinium corymbosum L..

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / therapeutic use*
  • Arthritis, Experimental / pathology
  • Arthritis, Experimental / prevention & control*
  • Blueberry Plants*
  • Caco-2 Cells
  • Carrageenan / toxicity
  • Dose-Response Relationship, Drug
  • Edema / chemically induced
  • Edema / pathology
  • Edema / prevention & control*
  • Fruit
  • Humans
  • Male
  • Plant Extracts / isolation & purification
  • Plant Extracts / therapeutic use*
  • Protective Agents / isolation & purification
  • Protective Agents / therapeutic use
  • Rats
  • Rats, Wistar
  • Treatment Outcome


  • Anti-Inflammatory Agents
  • Plant Extracts
  • Protective Agents
  • Carrageenan