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. 2016 Oct;17(10):605-6.
doi: 10.1038/nrm.2016.110. Epub 2016 Aug 24.

Coenzyme A: to make it or uptake it?

Ody C M Sibon  1 , Erick Strauss  2
Affiliations

Coenzyme A: to make it or uptake it?

Ody C M Sibon et al. Nat Rev Mol Cell Biol. 2016 Oct.

Abstract

The consensus has been that intracellular coenzyme A (CoA) is obtained exclusively by de novo biosynthesis via a universal, conserved five-step pathway in the cell cytosol. However, old and new evidence suggest that cells (and some microorganisms) have several strategies to obtain CoA, with 4'-phosphopantetheine (P-PantSH; the fourth intermediate in the canonical CoA biosynthetic pathway) serving as a 'nexus' metabolite.

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