Direct Cardiac Cellular Reprogramming for Cardiac Regeneration

Curr Treat Options Cardiovasc Med. 2016 Sep;18(9):58. doi: 10.1007/s11936-016-0480-8.


Direct cardiac cellular reprogramming of endogenous cardiac fibroblasts directly into induced cardiomyocytes is a highly feasible, promising therapeutic option for patients with advanced heart failure. The most successful cardiac reprogramming strategy will likely be a multimodal approach involving an optimal combination of cardio-differentiating factors, suppression of fibroblast gene expression, and induction of angiogenic factors.

Keywords: Cardiomyocyte; GMT; Gene therapy; Heart failure; Reprogramming; Transdifferentiation.

Publication types

  • Review