A Case of Ulcerative Colitis Following Acute Hepatitis Induced by Epstein-Barr Virus Infection

Korean J Gastroenterol. 2016 Aug 25;68(2):104-8. doi: 10.4166/kjg.2016.68.2.104.


Epstein-Barr virus (EBV) infection varies in its clinical manifestations and severity. EBV can be a causative agent of hepatitis and may have a role in the pathogenesis of chronic autoimmune diseases including inflammatory bowel disease. A 24-year-old woman was admitted to our hospital, presenting with fever and elevated liver enzymes. She was diagnosed with acute hepatitis and EBV infection according to serologic tests and liver biopsy. Within two months, she was re-admitted to our hospital, presenting with hematochezia and lower abdominal pain. She was diagnosed with ulcerative colitis. In situ hybridization for EBV was positive in initial liver biopsy and colon biopsy. Here we report an unusual case of acute EBV hepatitis followed at a short interval by ulcerative colitis.

Keywords: Epstein-Barr virus; Epstein-Barr virus infections; Hepatitis; Ulcerative colitis.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Colitis, Ulcerative / diagnosis*
  • Colitis, Ulcerative / etiology
  • Colitis, Ulcerative / virology
  • Colonoscopy
  • Epstein-Barr Virus Infections / complications
  • Epstein-Barr Virus Infections / diagnosis*
  • Epstein-Barr Virus Infections / virology
  • Female
  • Hepatitis, Viral, Human / diagnosis*
  • Hepatitis, Viral, Human / etiology
  • Hepatitis, Viral, Human / virology
  • Herpesvirus 4, Human / genetics
  • Herpesvirus 4, Human / isolation & purification
  • Humans
  • In Situ Hybridization
  • Liver / pathology
  • Liver / virology
  • Young Adult