Adjuvant radiation therapy in stage I seminoma: 20 years of oncologic results

Oncotarget. 2016 Nov 29;7(48):80077-80082. doi: 10.18632/oncotarget.11374.

Abstract

Aim: To report long term oncologic outcomes after adjuvant radiotherapy (RT) for stage I seminoma.

Method: We reviewed the complete data set for all patients treated at our institute between 1988 and 2005 for stage I seminoma with adjuvant RT after radical orchiectomy .

Results: A total of 85 patients were included. The median follow-up was 15 years. The 20-year overall survival (OS) and relapse free survival (RFS) were 92% and 96.3%, respectively. No severe acute and late complications were recorded. Overall 5.9% of patients had a second unrelated malignancy.

Conclusion: Adjuvant RT is an efficacious and safe treatment in stage I seminoma.

Keywords: chemotherapy; orchiectomy; radiotherapy; stage I seminoma; surveillance.

MeSH terms

  • Adult
  • Aged
  • Combined Modality Therapy
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Neoplasm Staging
  • Orchiectomy
  • Radiotherapy, Adjuvant*
  • Retrospective Studies
  • Seminoma / mortality
  • Seminoma / pathology
  • Seminoma / radiotherapy*
  • Seminoma / surgery*
  • Survival Analysis
  • Testicular Neoplasms / mortality
  • Testicular Neoplasms / pathology
  • Testicular Neoplasms / radiotherapy*
  • Testicular Neoplasms / surgery*
  • Treatment Outcome
  • Young Adult