[The Impact of Tumor Cell Proliferation on Occult Micrometastases, Tumor Recurrence and Patient Outcome Following Resection for Liver Malignancies]

Zentralbl Chir. 2016 Aug;141(4):375-82. doi: 10.1055/s-0042-108592. Epub 2016 Aug 24.
[Article in German]


Liver resection is currently considered to be essential part of the curative treatment of primary and secondary liver malignancies. However, long-term survival in these patients is limited by the high incidence of tumor recurrence. Recent clinical and experimental studies have indicated that cellular and molecular mechanisms associated with liver regeneration after partial hepatectomy may have a proliferative effect on occult micrometastases and circulating tumor cells and are thus responsible for recurrent disease. Growth factors and cytokines involved in liver regeneration have also been shown to influence tumour growth and metastasis. However, the underlying mechanisms explaining the interactions between regenerating liver tissue and tumour cell proliferation remain unclear. The development of modern agents specifically targeting these processes may improve disease-free and overall survival rates after oncological hepatectomy.

Publication types

  • Review

MeSH terms

  • Cell Proliferation / physiology*
  • Disease Progression
  • Hepatectomy*
  • Humans
  • Liver Neoplasms / mortality
  • Liver Neoplasms / pathology*
  • Liver Neoplasms / secondary*
  • Liver Neoplasms / surgery
  • Liver Regeneration / physiology*
  • Neoplasm Micrometastasis / pathology*
  • Neoplasm Micrometastasis / therapy
  • Neoplasm Recurrence, Local / mortality
  • Neoplasm Recurrence, Local / pathology*
  • Neoplasm Recurrence, Local / surgery
  • Neoplastic Cells, Circulating / pathology
  • Prognosis
  • Survival Analysis
  • Treatment Outcome