SuFEx Click: New Materials from SO x F and Silyl Ethers

Chemistry. 2016 Nov 7;22(46):16348-16354. doi: 10.1002/chem.201602926. Epub 2016 Aug 25.


New forms of click chemistry present new opportunities in materials science. Sulfur(VI) fluoride exchange (SuFEx) is a recently discovered click reaction between molecules containing SOx F groups and silyl ethers, two functionalities that are orthogonal to all other known click chemistries, that generates sulfate or sulfonate connections upon the addition of certain organobases or fluoride sources. SuFEx also has several important advantages over other click reactions in that it is insensitive to ambient oxygen and water, and its precursor materials, especially SOx F, are chemically, UV, and thermally inert. This Concept article focuses on the unique reactivity of SuFEx and its relation to building high molecular weight polymers and surface coatings, both of which make it a powerful new tool for materials science.

Keywords: click chemistry; materials science; polymerization; surface chemistry; thin films.