An RGS2 3'UTR polymorphism is associated with preeclampsia in overweight women

BMC Genet. 2016 Aug 24;17(1):121. doi: 10.1186/s12863-016-0428-8.


Background: Preeclampsia is a common and heterogeneous vascular syndrome of pregnancy. Its genetic risk profile is yet unknown and may vary between individuals and populations. The rs4606 3' UTR polymorphism of the Regulator of G-protein signaling 2 gene (RGS2) in the mother has been implicated in preeclampsia as well as in the development of chronic hypertension after preeclampsia. The RGS2 protein acts as an inhibitor of physiological vasoconstrictive pathways, and a low RGS2 level is associated with hypertension and obesity, two conditions that predispose to preeclampsia. We genotyped the rs4606 polymorphism in 1339 preeclamptic patients and in 697 controls from the Finnish Genetics of Preeclampsia Consortium (FINNPEC) cohort to study the association of the variant with preeclampsia.

Results: No association between rs4606 and preeclampsia was detected in the analysis including all women. However, the polymorphism was associated with preeclampsia in a subgroup of overweight women (body mass index ≥ 25 kg/m(2), and < 30 kg/m(2)) (dominant model; odds ratio, 1.64; 95 % confidence interval, 1.10-2.42).

Conclusions: Our results suggest that RGS2 might be involved in the pathogenesis of preeclampsia particularly in overweight women and contribute to their increased risk for hypertension and other types of cardiovascular disease later in life.

Keywords: Candidate gene study; Preeclampsia; Pregnancy; Regulator of G-protein signaling 2.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3' Untranslated Regions
  • Adult
  • Alleles
  • Biomarkers
  • Body Mass Index
  • Case-Control Studies
  • Female
  • Gene Expression Regulation
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Models, Biological
  • Odds Ratio
  • Overweight / complications*
  • Overweight / genetics*
  • Polymorphism, Single Nucleotide*
  • Pre-Eclampsia / diagnosis
  • Pre-Eclampsia / etiology*
  • Pre-Eclampsia / metabolism
  • Pregnancy
  • RGS Proteins / genetics*
  • RGS Proteins / metabolism
  • Risk Factors


  • 3' Untranslated Regions
  • Biomarkers
  • RGS Proteins
  • RGS2 protein, human