A conserved role of the RSC chromatin remodeler in the establishment of nucleosome-depleted regions

Curr Genet. 2017 May;63(2):187-193. doi: 10.1007/s00294-016-0642-y. Epub 2016 Aug 24.


The occupancy of nucleosomes governs access to the eukaryotic genomes and results from a combination of biophysical features and the effect of ATP-dependent remodelling complexes. Most promoter regions show a conserved pattern characterized by a nucleosome-depleted region (NDR) flanked by nucleosomal arrays. The conserved RSC remodeler was reported to be critical to establish NDR in vivo in budding yeast but other evidences suggested that this activity may not be conserved in fission yeast. By reanalysing and expanding previously published data, we propose that NDR formation requires, at least partially, RSC in both yeast species. We also discuss the most prominent biological role of RSC and the possibility that non-essential subunits do not define alternate versions of the complex.

Keywords: Chromatin; Mitosis; Nucleosome; RSC; Yeast.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphatases / genetics*
  • Adenosine Triphosphatases / metabolism
  • Chromatin Assembly and Disassembly / genetics*
  • Gene Expression Profiling
  • Gene Expression Regulation, Fungal
  • Nucleosomes / genetics*
  • Saccharomyces cerevisiae Proteins / genetics*
  • Saccharomyces cerevisiae Proteins / metabolism
  • Saccharomycetales / genetics
  • Saccharomycetales / metabolism
  • Schizosaccharomyces / genetics
  • Schizosaccharomyces / metabolism
  • Schizosaccharomyces pombe Proteins / genetics*
  • Schizosaccharomyces pombe Proteins / metabolism
  • Species Specificity


  • Nucleosomes
  • Saccharomyces cerevisiae Proteins
  • Schizosaccharomyces pombe Proteins
  • Adenosine Triphosphatases