Effect of Ginger Supplementation on Proinflammatory Cytokines in Older Patients with Osteoarthritis: Outcomes of a Randomized Controlled Clinical Trial

J Nutr Gerontol Geriatr. Jul-Sep 2016;35(3):209-18. doi: 10.1080/21551197.2016.1206762.

Abstract

There is limited evidence that ginger powder consumption can relieve pain and inflammation due to specific anti-inflammatory phytochemical constitutents. This study investigates the effect of ginger supplementation on proinflammatory factors in participants (n = 120) of a randomized double-blind placebo-controlled 3-month clinical trial investigating knee osteoarthritis. Patients were randomly assigned to one of two groups: the ginger group (GG) or the placebo group (PG). Administered daily for 3 months, participants in the GG intervention received capsules containing 500 mg of ginger powder, while PG participants received capsules filled with 500 mg starch. Serum samples collected at baseline and 3 months were analyzed for serum levels of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). At baseline, proinflammatory cytokine concentrations did not differ by group. However, at 3 months, both cytokines decreased in the GG relative to the PG. The results of this study indicate that ginger supplementation may have a promising benefits for knee osteoarthritis and may, therefore, may warrant further study.

Keywords: Osteoarthritis; ginger; inflammation.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Cytokines / blood
  • Dietary Supplements*
  • Double-Blind Method
  • Female
  • Ginger*
  • Health Services for the Aged
  • Humans
  • Male
  • Middle Aged
  • Osteoarthritis, Knee / blood
  • Osteoarthritis, Knee / drug therapy*
  • Pain Measurement
  • Phytotherapy
  • Treatment Outcome

Substances

  • Cytokines