Abstract
In this randomized, double-blind, crossover trial, we evaluated whether 4-week supplementation with guanidinoacetic acid (GAA) is superior to creatine in facilitating creatine levels in healthy men (n = 5). GAA (3.0 g/day) resulted in a more powerful rise (up to 16.2%) in tissue creatine levels in vastus medialis muscle, middle-cerebellar peduncle, and paracentral grey matter, as compared with creatine (P < 0.05). These results indicate that GAA as a preferred alternative to creatine for improved bioenergetics in energy-demanding tissues.
Keywords:
Vastus medialis muscle; bioenergetics; bioénergétique; cerebellum; cervelet; homocysteine; homocystéine; muscle vaste interne.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Adult
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Biomarkers / blood
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Creatine / administration & dosage*
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Creatine / adverse effects
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Cross-Over Studies
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Dietary Supplements* / adverse effects
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Double-Blind Method
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Follow-Up Studies
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Frontal Lobe / metabolism*
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Glycine / administration & dosage
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Glycine / adverse effects
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Glycine / analogs & derivatives*
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Homocysteine / blood
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Humans
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Hyperhomocysteinemia / blood
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Hyperhomocysteinemia / etiology
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Hyperhomocysteinemia / metabolism
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Magnetic Resonance Spectroscopy
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Male
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Middle Cerebellar Peduncle / metabolism*
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Neurons / metabolism
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Performance-Enhancing Substances / administration & dosage*
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Performance-Enhancing Substances / adverse effects
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Pilot Projects
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Quadriceps Muscle / metabolism*
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Serbia
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Up-Regulation
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Young Adult
Substances
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Biomarkers
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Performance-Enhancing Substances
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Homocysteine
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glycocyamine
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Creatine
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Glycine