A New 5(6→7)abeo-sterol from the twigs of Podocarpus fleuryi

Nat Prod Res. 2017 Jan;31(2):175-180. doi: 10.1080/14786419.2016.1224870. Epub 2016 Aug 25.

Abstract

A new 5(6→7)abeo-sterol with rarely reported [6-5-6-5]-fused rings, 3β,5β,6-trihydroxyl-B-norsitostane (1), along with 10 known compounds were isolated from the twigs of Podocarpus fleuryi. Their structures were elucidated by means of extensive spectroscopic analysis. Compound 1 was assessed for their cytotoxicity against five human tumour cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW-480), and the result showed that it had no activity.

Keywords: Podocarpaceae; Podocarpus fleuryi; abeo-sterol.

MeSH terms

  • Antineoplastic Agents, Phytogenic
  • Cell Line, Tumor
  • China
  • Drug Screening Assays, Antitumor
  • HL-60 Cells
  • Humans
  • Magnetic Resonance Spectroscopy
  • Pinus / chemistry*
  • Plant Extracts / chemistry
  • Plant Stems / chemistry*
  • Spectrometry, Mass, Electrospray Ionization
  • Sterols / chemistry*
  • Sterols / pharmacology

Substances

  • 3beta,5beta,6-trihydroxyl-B-norsitostane
  • Antineoplastic Agents, Phytogenic
  • Plant Extracts
  • Sterols