Ambient Aqueous Synthesis of Ultrasmall PEGylated Cu 2-x Se Nanoparticles as a Multifunctional Theranostic Agent for Multimodal Imaging Guided Photothermal Therapy of Cancer

Adv Mater. 2016 Oct;28(40):8927-8936. doi: 10.1002/adma.201602193. Epub 2016 Aug 25.

Abstract

Ultrasmall PEGylated Cu2-x Se nanoparticles with strong near-infrared absorption have been prepared by an ambient aqueous method. The resultant water-soluble and biocompatible nanoparticles are demonstrated to be a novel nanotheranostic agent for effective deep-tissue photoacoustic imaging, computed tomography imaging, single-photon emission computed tomography imaging, and photothermal therapy of cancer.

Keywords: Cu2-xSe nanoparticles; computed tomography imaging; photoacoustic imaging; photothermal therapy; single-photon emission computed tomography.