Abstract
We describe a young woman who developed POTS with positive serum anti-NMDA receptor antibodies and no evidence of encephalitis after vaccination with HPV vaccine, Cervarix. Her symptoms improved significantly with immunomodulatory therapy and re-occurred after immunomodulatory therapy was stopped, suggesting an autoimmune etiology of POTS after vaccination.
Keywords:
Anti-NMDA receptor antibodies; Human papillomavirus vaccination; Orthostatic intolerance; Plasmapheresis; Postural tachycardia syndrome.
MeSH terms
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Adolescent
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Antibodies / blood*
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Female
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Humans
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Immunologic Factors / therapeutic use
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Papillomavirus Vaccines / adverse effects*
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Plasmapheresis
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Postural Orthostatic Tachycardia Syndrome / blood
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Postural Orthostatic Tachycardia Syndrome / chemically induced*
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Postural Orthostatic Tachycardia Syndrome / immunology
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Postural Orthostatic Tachycardia Syndrome / therapy
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Receptors, N-Methyl-D-Aspartate / immunology*
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Vaccination / adverse effects
Substances
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Antibodies
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Immunologic Factors
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Papillomavirus Vaccines
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Receptors, N-Methyl-D-Aspartate
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human papillomavirus vaccine, L1 type 16, 18