Postural tachycardia syndrome (POTS) with anti-NMDA receptor antibodies after human papillomavirus vaccination

Immunol Res. 2017 Feb;65(1):282-284. doi: 10.1007/s12026-016-8855-1.

Abstract

We describe a young woman who developed POTS with positive serum anti-NMDA receptor antibodies and no evidence of encephalitis after vaccination with HPV vaccine, Cervarix. Her symptoms improved significantly with immunomodulatory therapy and re-occurred after immunomodulatory therapy was stopped, suggesting an autoimmune etiology of POTS after vaccination.

Keywords: Anti-NMDA receptor antibodies; Human papillomavirus vaccination; Orthostatic intolerance; Plasmapheresis; Postural tachycardia syndrome.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antibodies / blood*
  • Female
  • Humans
  • Immunologic Factors / therapeutic use
  • Papillomavirus Vaccines / adverse effects*
  • Plasmapheresis
  • Postural Orthostatic Tachycardia Syndrome / blood
  • Postural Orthostatic Tachycardia Syndrome / chemically induced*
  • Postural Orthostatic Tachycardia Syndrome / immunology
  • Postural Orthostatic Tachycardia Syndrome / therapy
  • Receptors, N-Methyl-D-Aspartate / immunology*
  • Vaccination / adverse effects

Substances

  • Antibodies
  • Immunologic Factors
  • Papillomavirus Vaccines
  • Receptors, N-Methyl-D-Aspartate
  • human papillomavirus vaccine, L1 type 16, 18