Precision Fluid Management in Continuous Renal Replacement Therapy

Blood Purif. 2016;42(3):266-78. doi: 10.1159/000448528. Epub 2016 Aug 26.


Fluid management during continuous renal replacement therapy (CRRT) in critically ill patients is a dynamic process that encompasses 3 inter-related goals: maintenance of the patency of the CRRT circuit, maintenance of plasma electrolyte and acid-base homeostasis and regulation of patient fluid balance. In this article, we report the consensus recommendations of the 2016 Acute Disease Quality Initiative XVII conference on 'Precision Fluid Management in CRRT'. We discuss the principles of fluid management, describe various prescription methods to achieve circuit integrity and introduce the concept of integrated fluid balance for tailoring fluid balance to the needs of the individual patient. We suggest that these recommendations could serve to develop the best clinical practice and standards of care for fluid management in patients undergoing CRRT. Finally, we identify and highlight areas of uncertainty in fluid management and set an agenda for future research.

Publication types

  • Review

MeSH terms

  • Citrates
  • Critical Illness / therapy
  • Dialysis Solutions
  • Disease Management
  • Fluid Therapy* / methods
  • Homeostasis
  • Humans
  • Plasma
  • Precision Medicine*
  • Renal Replacement Therapy* / methods
  • Time Factors
  • Water-Electrolyte Balance


  • Citrates
  • Dialysis Solutions