A code within a code: how codons influence mRNA stability

EMBO J. 2016 Oct 4;35(19):2064-2065. doi: 10.15252/embj.201695283. Epub 2016 Aug 25.


The genetic code was deciphered more than 50 years ago, but we are only now becoming aware of a second, hidden code. It is the concept of “codon optimality” that enters the scene of developmental and homeostatic gene expression, linking translation rates, mRNA stability, and tRNA abundance. Both at the biological and methodological levels, work by Giraldez and colleagues in this issue of The EMBO Journal paves the way for further analyses of such key regulatory mechanisms.

Publication types

  • Comment

MeSH terms

  • Amino Acids / genetics
  • Codon*
  • Genetic Code
  • Models, Genetic
  • RNA Stability*


  • Amino Acids
  • Codon