Clinical Significance of Preoperative Neutrophil - to - Lymphocyte Ratio in Renal Cell Carcinoma

Int Braz J Urol. Jul-Aug 2016;42(4):678-84. doi: 10.1590/S1677-5538.IBJU.2015.0397.


Introduction: We investigated the prognostic significance of the neutrophil-to-lymphocyte ratio on tumor stage and Fuhrman nuclear grade in renal cell carcinoma.

Methods: The records of 432 patients with RCC who underwent radical or partial nephrectomy between 2005 and 2014 were retrospectively reviewed. Patients were classified as group lower tumor stage(T1 + T2) and higher(T3 + T4). As like tumor stage, Fuhrman nuclear grade were classified lower (G1+G2) and higher(G3+G4) too. The best NLR cut off value was 3.01.Two sample t-test or Mann-Whitney U-test used for the continuous variables and a chi-square test or Fisher's exact test used for the categorical variables.

Results: Among the 432 total patients analyzed in our study, there were 275 males (63.7%) and 157 females (36.3%). Mean laboratory values were CRP 2.73 ± 1.93 mg/ dL (normal less than 0.3), neutrophil count 4,23 ± 1.46/μL, lymphocyte count 1,61 ± 0,61/μL and NLR 2.64 ± 1.24. According to our data, statistically pretreatment NLR significantly correlated with CRP (p<0.0001). And tumor patologic stage (p=0.08), tumor histologic grade (p<0.001) was significantly associated with NLR.

Discussion: We compared the relationship of preoperative NLR and NC parameters with RCC tumor stage and grade. And NLR were found to have statistically significant higher T stage and grade at RCC. Further studies with more patients are needed to confirm our study.

Keywords: Carcinoma, Renal Cell; Epithelium; Neutrophils.

MeSH terms

  • Aged
  • Carcinoma, Renal Cell / blood
  • Carcinoma, Renal Cell / pathology*
  • Carcinoma, Renal Cell / surgery
  • Female
  • Humans
  • Kidney Neoplasms / blood
  • Kidney Neoplasms / pathology*
  • Kidney Neoplasms / surgery
  • Lymphocyte Count
  • Lymphocytes*
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Neutrophils*
  • Preoperative Care
  • Prognosis
  • Retrospective Studies
  • Risk Factors