β-Catenin-Independent Roles of Wnt/LRP6 Signaling

Sergio P Acebron; Christof Niehrs

doi:10.1016/j.tcb.2016.07.009

β-Catenin-Independent Roles of Wnt/LRP6 Signaling

Trends Cell Biol. 2016 Dec;26(12):956-967. doi: 10.1016/j.tcb.2016.07.009. Epub 2016 Aug 24.

Authors

Sergio P Acebron¹, Christof Niehrs²

Affiliations

¹ Division of Molecular Embryology, Deutsches Krebsforschungszentrum (DKFZ)-Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH) Alliance, 69120 Heidelberg, Germany. Electronic address: s.perezacebron@DKFZ-Heidelberg.de.
² Division of Molecular Embryology, Deutsches Krebsforschungszentrum (DKFZ)-Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH) Alliance, 69120 Heidelberg, Germany; Institute of Molecular Biology, 55128 Mainz, Germany. Electronic address: Niehrs@DKFZ-Heidelberg.de.

PMID: 27568239
DOI: 10.1016/j.tcb.2016.07.009

Abstract

Wnt/LRP6 signaling is best known for the β-catenin-dependent regulation of target genes. However, pathway branches have recently emerged, including Wnt/STOP signaling, which act independently of β-catenin and transcription. We review here the molecular mechanisms underlying β-catenin-independent Wnt/LRP6 signaling cascades and their implications for cell biology, development, and physiology.

Keywords: GSK3; Wnt/STOP; mitosis; post-transcriptional Wnt signaling; proteolysis; β-catenin.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Humans
Low Density Lipoprotein Receptor-Related Protein-6 / metabolism*
Models, Biological
Protein Stability
Receptor Cross-Talk
Wnt Signaling Pathway*
beta Catenin / metabolism*

Substances

Low Density Lipoprotein Receptor-Related Protein-6
beta Catenin