miRNA-Dependent Activation of mRNA Translation

Microrna. 2016;5(2):83-86. doi: 10.2174/2211536605666160825151201.

Abstract

MicroRNAs (miRNAs) are small and important RNA molecules. They can regulate gene expression at different levels. Although their biogenesis has been well documented, elucidation of miRNA-dependent activation of mRNA translation has just begun. Here, we highlighted different patterns of miRNA-dependent activation of mRNA translation: miRNA can activate mRNA translation through binding different target sites; in different sub-cellular locations; under different cellular circumstances. MiRNA-dependent activation of mRNA translation suggests unexpected functions of miRNA, that could provide new clues in functional studies of other ncRNAs.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites / genetics
  • Gene Expression Regulation / genetics*
  • Humans
  • MicroRNAs / genetics*
  • Protein Biosynthesis / genetics*
  • RNA, Messenger / genetics*

Substances

  • MicroRNAs
  • RNA, Messenger