[Extracellular vesicles and their role in hematological malignancies]

Orv Hetil. 2016 Aug;157(35):1379-84. doi: 10.1556/650.2016.30532.
[Article in Hu]

Abstract

Extracellular vesicles are produced in all organisms. The most intensively investigated categories of extracellular vesicles include apoptotic bodies, microvesicles and exosomes. Among a very wide range of areas, their role has been confirmed in intercellular communication, immune response and angiogenesis (in both physiological and pathological conditions). Their alterations suggest the potential use of them as biomarkers. In this paper the authors give an insight into the research of extracellular vesicles in general, and then focus on published findings in hematological malignancies. Quantitative and qualitative changes of microvesicles and exosomes may have value in diagnostics, prognostics and minimal residual disease monitoring of hematological malignancies. The function of extracellular vesicles in downregulation of natural killer cells' activity has been demonstrated in acute myeloid leukemia. In chronic lymphocytic leukemia, microvesicles seem to play a role in drug resistance. Orv. Hetil., 2016, 157(35), 1379-1384.

Keywords: biomarker; exosoma; exosome; extracellular vesicle; extracelluláris vesicula; leukaemia; leukemia; microvesicle/microparticle; microvesicula/microparticula.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / blood*
  • Cell Communication
  • Cell-Derived Microparticles / metabolism
  • Extracellular Vesicles / metabolism*
  • Hematologic Neoplasms / blood*
  • Humans
  • Particle Size

Substances

  • Biomarkers, Tumor