Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Oct;19(10):1331-40.
doi: 10.1038/nn.4376. Epub 2016 Aug 29.

Visceral Motor Neuron Diversity Delineates a Cellular Basis for Nipple- And Pilo-Erection Muscle Control

Affiliations

Visceral Motor Neuron Diversity Delineates a Cellular Basis for Nipple- And Pilo-Erection Muscle Control

Alessandro Furlan et al. Nat Neurosci. .

Abstract

Despite the variety of physiological and target-related functions, little is known regarding the cellular complexity in the sympathetic ganglion. We explored the heterogeneity of mouse stellate and thoracic ganglia and found an unexpected variety of cell types. We identified specialized populations of nipple- and pilo-erector muscle neurons. These neurons extended axonal projections and were born among other neurons during embryogenesis, but remained unspecialized until target organogenesis occurred postnatally. Target innervation and cell-type specification was coordinated by an intricate acquisition of unique combinations of growth factor receptors and the initiation of expression of concomitant ligands by the nascent erector muscles. Overall, our results provide compelling evidence for a highly sophisticated organization of the sympathetic nervous system into discrete outflow channels that project to well-defined target tissues and offer mechanistic insight into how diversity and connectivity are established during development.

Similar articles

See all similar articles

Cited by 22 articles

See all "Cited by" articles

References

    1. Acta Physiol Scand. 1982 Dec;116(4):477-80 - PubMed
    1. Nature. 1994 Jan 27;367(6461):380-3 - PubMed
    1. J Neurosci. 2013 Jun 26;33(26):10667-75 - PubMed
    1. Am J Physiol. 1998 Oct;275(4 Pt 2):R1247-55 - PubMed
    1. Annu Rev Neurosci. 1999;22:541-66 - PubMed

Publication types

Substances

LinkOut - more resources

Feedback