Brief Report: Cesarean Delivery and Subsequent Fecundability

Epidemiology. 2016 Nov;27(6):889-93. doi: 10.1097/EDE.0000000000000553.

Abstract

Background: Studies have shown that cesarean delivery is associated with fewer subsequent births relative to vaginal delivery, but it is unclear whether confounding by pregnancy intention or indication for surgery explained these results. We evaluated the association between cesarean delivery and subsequent fecundability among 910 primiparous women after singleton live birth.

Methods: In a cohort of Danish women planning pregnancy (2007-2012), obstetrical history was obtained via registry linkage; time-to-pregnancy and covariate data were collected via questionnaire. Fecundability ratios (FRs) and 95% confidence intervals (CIs) were adjusted for potential confounders.

Results: Relative to spontaneous vaginal delivery, emergency cesarean delivery with cephalic presentation showed little association with fecundability (FR = 1.0, 95% CI = 0.83, 1.3), but cesarean delivery with breech presentation (FR = 0.72, 95% CI = 0.53, 0.97) and planned cesarean delivery with cephalic presentation (FR = 0.51, 95% CI = 0.25, 1.0) were associated with reduced fecundability.

Conclusions: The cesarean-fecundability association varied by previous fetal presentation and emergency status.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural

MeSH terms

  • Adolescent
  • Adult
  • Cesarean Section / adverse effects*
  • Denmark / epidemiology
  • Female
  • Follow-Up Studies
  • Humans
  • Infertility, Female / epidemiology
  • Infertility, Female / etiology*
  • Parity*
  • Postoperative Complications / epidemiology
  • Postoperative Complications / etiology*
  • Pregnancy
  • Risk Factors
  • Time-to-Pregnancy
  • Young Adult