Cerebral Autoregulation Real-Time Monitoring

PLoS One. 2016 Aug 29;11(8):e0161907. doi: 10.1371/journal.pone.0161907. eCollection 2016.


Cerebral autoregulation is a mechanism which maintains constant cerebral blood flow (CBF) despite changes in mean arterial pressure (MAP). Assessing whether this mechanism is intact or impaired and determining its boundaries is important in many clinical settings, where primary or secondary injuries to the brain may occur. Herein we describe the development of a new ultrasound tagged near infra red light monitor which tracks CBF trends, in parallel, it continuously measures blood pressure and correlates them to produce a real time autoregulation index. Its performance is validated in both in-vitro experiment and a pre-clinical case study. Results suggest that using such a tool, autoregulation boundaries as well as its impairment or functioning can be identified and assessed. It may therefore assist in individualized MAP management to ensure adequate organ perfusion and reduce the risk of postoperative complications, and might play an important role in patient care.

MeSH terms

  • Animals
  • Arterial Pressure / physiology
  • Blood Flow Velocity / physiology
  • Blood Pressure / physiology
  • Cerebrovascular Circulation / physiology*
  • Female
  • Homeostasis / physiology
  • Swine

Grants and funding

The study was sponsored by Ornim Medical LTD. Ornim Medical LTD provided support in the form of salaries for authors [AT, ER, SL, ZS, IB, NB, MK], but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.