Neuromyelitis optica spectrum disorders in children and adolescents

Neurology. 2016 Aug 30;87(9 Suppl 2):S59-66. doi: 10.1212/WNL.0000000000002824.


Neuromyelitis optica (NMO) is a severe autoimmune disease of the CNS characterized by recurrent inflammatory events primarily involving the optic nerves and spinal cord. NMO is infrequent in children, but early recognition is important to start adequate treatment. In this article, we review the evolving diagnostic criteria of NMO and provide an update on the clinical and neuroimaging spectrum of the disorder in pediatric patients, including current knowledge on immunopathogenesis and treatment recommendations for children with NMO.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Autoantibodies / blood
  • Child
  • Humans
  • Neuroimaging
  • Neuromyelitis Optica* / diagnosis
  • Neuromyelitis Optica* / epidemiology
  • Neuromyelitis Optica* / therapy
  • Spinal Cord / pathology


  • Autoantibodies