Genomic landscape of the Greater Middle East

Nat Genet. 2016 Aug 30;48(9):978-9. doi: 10.1038/ng.3652.


Study of the Greater Middle East (GME), home to approximately 10% of the world's population, has made invaluable contributions to the characterization of rare genetic disease, especially recessive conditions arising from the tradition of consanguinity and large families with multiple children. A new study now reports 1,111 unrelated exomes from the GME and provides a comprehensive view of genetic variation for enhanced discovery of disease-associated genes.

Publication types

  • Comment

MeSH terms

  • Consanguinity*
  • Genes, Recessive
  • Genetic Variation*
  • Genomics
  • Humans
  • Middle East