The incidence of diabetes has increased 7 to 10-fold in the past 50 y. Although increased sugar consumption, obesity, and lack of exercise certainly contribute, the effect of environmental toxins may be far greater. The data are so compelling that some researchers now label these toxins as diabetogens. This editorial summarizes the research showing which toxins are the worst offenders, how they disrupt blood sugar control, where they come from, how to assess body load, and strategies for detoxification and excretion.