Iminophenyl Oxazolinylphenylamine for Enantioselective Cobalt-Catalyzed Hydrosilylation of Aryl Ketones

Org Lett. 2016 Sep 16;18(18):4658-61. doi: 10.1021/acs.orglett.6b02260. Epub 2016 Aug 30.

Abstract

A new family of chiral iminophenyl oxazolinylphenylamines (IPOPA) was designed and synthesized through three steps from commercially available starting materials. An efficient cobalt-catalyzed asymmetric hydrosilylation of simple ketones with a low catalyst loading of CoCl2 and IPOPA was developed to afford chiral alcohols in good yields with high enantioselectivities.

Publication types

  • Research Support, Non-U.S. Gov't