New Onset Hypertension Linked to Generic Cyclosporine Substitution in Post-Renal Transplant Patient

Am J Nephrol. 2016;44(3):219-23. doi: 10.1159/000449021. Epub 2016 Aug 31.


This is case report and review of the literature focused on generic substitutions of cyclosporine and its consequences. The pharmacokinetics and pharmacodynamics of the generic substitutions are clear different than the parent compound Sandimmune and can lead to different outcomes, as was the case in this report. A detailed accounting of the patients history led to the discovery of the problem and sorting back to a the branded drug supported the hypothesis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Cyclosporine / adverse effects
  • Cyclosporine / therapeutic use*
  • Drug Substitution / adverse effects*
  • Drugs, Generic / adverse effects*
  • Female
  • Humans
  • Hypertension / chemically induced*
  • Kidney Transplantation
  • Middle Aged


  • Drugs, Generic
  • Cyclosporine