MNX1 Is Oncogenically Upregulated in African-American Prostate Cancer

Cancer Res. 2016 Nov 1;76(21):6290-6298. doi: 10.1158/0008-5472.CAN-16-0087. Epub 2016 Aug 30.

Abstract

Incidence and mortality rates for prostate cancer are higher in African-American (AA) men than in European-American (EA) men, but the biologic basis for this disparity is unclear. We carried out a detailed analysis of gene expression changes in prostate cancer compared with their matched benign tissues in a cohort of AA men and compared them with existing data from EA men. In this manner, we identified MNX1 as a novel oncogene upregulated to a relatively greater degree in prostate cancer from AA men. Androgen and AKT signaling play a central role in the pathogenesis of prostate cancer and we found that both of these signaling pathways increased MNX1 expression. MNX1 in turn upregulated lipid synthesis by stimulating expression of SREBP1 and fatty acid synthetase. Our results define MNX1 as a novel targetable oncogene increased in AA prostate cancer that is associated with aggressive disease. Cancer Res; 76(21); 6290-8. ©2016 AACR.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, N.I.H., Extramural

MeSH terms

  • African Americans
  • Animals
  • Cell Line, Tumor
  • Gene Expression Regulation, Neoplastic*
  • Homeodomain Proteins / genetics*
  • Humans
  • Male
  • Mice
  • Oncogenes*
  • Prostatic Neoplasms / ethnology
  • Prostatic Neoplasms / genetics*
  • Proto-Oncogene Proteins c-akt / physiology
  • Receptors, Androgen / physiology
  • Sterol Regulatory Element Binding Protein 1 / genetics
  • Transcription Factors / genetics*

Substances

  • AR protein, human
  • Homeodomain Proteins
  • MNX1 protein, human
  • Receptors, Androgen
  • SREBF1 protein, human
  • Sterol Regulatory Element Binding Protein 1
  • Transcription Factors
  • Proto-Oncogene Proteins c-akt