Slit-Robo signaling

Development. 2016 Sep 1;143(17):3037-44. doi: 10.1242/dev.132829.

Abstract

Slits are secreted proteins that bind to Roundabout (Robo) receptors. Slit-Robo signaling is best known for mediating axon repulsion in the developing nervous system. However, in recent years the functional repertoire of Slits and Robo has expanded tremendously and Slit-Robo signaling has been linked to roles in neurogenesis, angiogenesis and cancer progression among other processes. Likewise, our mechanistic understanding of Slit-Robo signaling has progressed enormously. Here, we summarize new insights into Slit-Robo evolutionary and system-dependent diversity, receptor-ligand interactions, signaling crosstalk and receptor activation.

Keywords: Angiogenesis; Axon guidance; Development; Migration; Robo; Slit.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Drosophila Proteins / genetics
  • Drosophila Proteins / metabolism*
  • Models, Biological
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism*
  • Receptors, Immunologic / genetics
  • Receptors, Immunologic / metabolism*
  • Roundabout Proteins
  • Signal Transduction / genetics
  • Signal Transduction / physiology*

Substances

  • Drosophila Proteins
  • Nerve Tissue Proteins
  • Receptors, Immunologic
  • sli protein, Drosophila