Endothelial progenitor cells dysfunction and impaired tissue reparation: The missed link in diabetes mellitus development

Diabetes Metab Syndr. Jul-Sep 2017;11(3):215-220. doi: 10.1016/j.dsx.2016.08.007. Epub 2016 Aug 23.


Diabetes mellitus (DM) is considered a leading cause of premature cardiovascular (CV) mortality and morbidity in general population and in individuals with known CV disease. Recent animal and clinical studies have shown that reduced number and weak function of endothelial progenitor cells (EPCs) may not only indicate to higher CV risk, but contribute to the impaired heart and vessels reparation in patients with DM. Moreover, EPCs having a protective impact on the vasculature may mediate the functioning of other organs and systems. Therefore, EPCs dysfunction is probably promising target for DM treatment strategy, while the role of restoring of EPCs number and functionality in CV risk diminish and reduce of DM-related complications is not fully clear. The aim of the review is summary of knowledge regarding EPCs dysfunction in DM patients.

Keywords: Angiogenesis; Cardiovascular complications; Diabetes mellitus; Endothelial progenitor cells; Reparation.

Publication types

  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus / etiology*
  • Diabetes Mellitus / pathology
  • Diabetes Mellitus / physiopathology*
  • Disease Progression
  • Endothelial Progenitor Cells / pathology
  • Endothelial Progenitor Cells / physiology*
  • Humans