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, 75 (6), 2574-8

The Beta Bulge: A Common Small Unit of Nonrepetitive Protein Structure

The Beta Bulge: A Common Small Unit of Nonrepetitive Protein Structure

J S Richardson et al. Proc Natl Acad Sci U S A.

Abstract

A beta bulge is a region between two consecutive beta-type hydrogen bonds which includes two residues (positions 1 and 2) on one strand opposite a single residue (position x) on the other strand. Compared to regular beta structure, a beta bulge puts the usual alternation of side-chain direction out of register on one of the strands, introduces a slight bend in the beta sheet, and locally accentuates the usual right-handed strand twist. Almost all beta bulges are between antiparallel strands, usually between a narrow rather than a wide pair of hydrogen bonds. Ninety-one examples are listed. The two commonest types are the "classic" beta bulge, with position 1 in approximately alpha-helical conformation, and the "G1" beta bulge, with a required glycine at position 1 in approximately left-handed alpha-helical conformation, G1 bulges almost always occur in combination with a type II tight turn. The functional roles of beta bulges probably include compensating for the effects of a single-residue insertion or deletion within beta structure and providing the strong local twist required for form closed beta barrel structures.

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References

    1. Nature. 1977 Aug 11;268(5620):495-500 - PubMed
    1. Nature. 1967 Apr 22;214(5086):363-5 - PubMed
    1. J Biol Chem. 1977 Jan 25;252(2):776-85 - PubMed
    1. Proc Natl Acad Sci U S A. 1978 Jun;75(6):2674-8 - PubMed
    1. Biochemistry. 1977 Apr 19;16(8):1720-5 - PubMed

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