Hereditary angioedema and pregnancy: successful management of recurrent and frequent attacks of angioedema with C1-inhibitor concentrate, danazol and tranexamic acid - a case report

Obstet Med. 2009 Sep;2(3):123-5. doi: 10.1258/om.2009.090003. Epub 2009 Sep 1.


Hereditary angioedema (HAE) is a rare but potentially life-threatening condition caused by deficiency of C1 esterase inhibitor. It is characterized by subcutaneous swelling in any part of the skin, gastrointestinal and respiratory tracts. We present the case of a pregnant woman with known HAE that deteriorated during pregnancy with frequent attacks that were managed successfully with danazol, tranexamic acid and regular intravenous administration of C1 esterase inhibitor.

Keywords: C1 esterase inhibitor; C1-INH; hereditary angioedema; pregnancy.

Publication types

  • Case Reports