Hypertensive disorders of pregnancy and outcomes of preterm infants of 24 to 28 weeks' gestation

J Perinatol. 2016 Dec;36(12):1067-1072. doi: 10.1038/jp.2016.133. Epub 2016 Sep 1.


Objective: To examine the relationship between hypertensive disorders of pregnancy (HDPs) and mortality and major morbidities in preterm neonates born at 24 to 28 weeks of gestation.

Study design: Using an international cohort, we retrospectively studied 27 846 preterm neonates born at 240 to 286 weeks of gestation during 2007 to 2010 from 6 national neonatal databases. The incidence of HDP was compared across countries, and multivariable logistic regression analyses were conducted to examine the association of HDP and neonatal outcomes including mortality to discharge, bronchopulmonary dysplasia, severe brain injury, necrotizing enterocolitis and treated retinopathy of prematurity.

Results: The incidence of HDP in the entire cohort was 13% (range 11 to 16% across countries). HDP was associated with reduced odds of mortality (adjusted odds ratio (aOR) 0.77; 95% confidence interval (CI) 0.67 to 0.88), severe brain injury (aOR 0.74; 95% CI 0.62 to 0.89) and treated retinopathy (aOR 0.82; 95% CI 0.70 to 0.96), but increased odds of bronchopulmonary dysplasia (aOR 1.16; 95% CI 1.05 to 1.27).

Conclusions: In comparison with neonates born to mothers without HDP, neonates of HDP mothers had lower odds of mortality, severe brain injury and treated retinopathy, but higher odds of bronchopulmonary dysplasia. The impact of maternal HDP on newborn outcomes was inconsistent across outcomes and among countries; therefore, further international collaboration to standardize terminology, case definition and data capture is warranted.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Birth Injuries / epidemiology
  • Bronchopulmonary Dysplasia / epidemiology
  • Case-Control Studies
  • Databases, Factual
  • Enterocolitis, Necrotizing / epidemiology
  • Female
  • Gestational Age
  • Humans
  • Hypertension, Pregnancy-Induced / epidemiology*
  • Incidence
  • Infant
  • Infant Mortality
  • Infant, Extremely Premature*
  • Infant, Newborn
  • Logistic Models
  • Odds Ratio
  • Pregnancy
  • Pregnancy Outcome / epidemiology*
  • Retinopathy of Prematurity / epidemiology
  • Retrospective Studies