Current evidence on the health-beneficial effects of berry fruits in the prevention and treatment of metabolic syndrome

Curr Opin Clin Nutr Metab Care. 2016 Nov;19(6):446-452. doi: 10.1097/MCO.0000000000000322.


Purpose of review: Berries belong to the best dietary sources of bioactive compounds, which exert a synergistic and cumulative effect on promotion of human health and prevention of diseases. The present review presents the most recent findings of animal and human studies regarding the health benefits of berries in terms of prevention and treatment of obesity, hypertension, type 2 diabetes, dyslipidemia, and nonalcoholic fatty liver disease.

Recent findings: In the last years, there was a growing number of evidence from human epidemiological and interventional studies, which emphasized the role of berries in the management of metabolic diseases. Based on the results from recent clinical trials, it can be established that a berry diet rich in antioxidants and bioactive phytochemicals has beneficial effects on hepatic function, increase of insulin sensitivity and high-density lipoprotein-cholesterol, decrease of serum glucose and low-density lipoprotein-cholesterol, and finally is inversely associated with the incidence of type 2 diabetes.

Summary: Numerous recent studies have shown that berries provide great benefits in preventing or mitigating metabolic disorders. The results of this review indicate that regular long-term consumption of different berries could potentially delay the progression of metabolic syndrome and comorbidities.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants
  • Cardiovascular Diseases / prevention & control
  • Cardiovascular Diseases / therapy
  • Diabetes Mellitus, Type 2 / prevention & control
  • Diabetes Mellitus, Type 2 / therapy
  • Diet
  • Dyslipidemias / prevention & control
  • Dyslipidemias / therapy
  • Fruit*
  • Health Promotion
  • Humans
  • Hypertension / prevention & control
  • Hypertension / therapy
  • Metabolic Syndrome / prevention & control*
  • Metabolic Syndrome / therapy*
  • Non-alcoholic Fatty Liver Disease / prevention & control
  • Non-alcoholic Fatty Liver Disease / therapy
  • Obesity / prevention & control
  • Obesity / therapy
  • Phytotherapy
  • Randomized Controlled Trials as Topic


  • Antioxidants