Oral Cryotherapy for Preventing Oral Mucositis in Patients Receiving Cancer Treatment

JAMA Oncol. 2016 Oct 1;2(10):1365-1366. doi: 10.1001/jamaoncol.2016.2680.


Clinical question: In patients receiving treatment for cancer, does oral cryotherapy prevent oral mucositis?

Bottom line: Oral cryotherapy is effective for the prevention of oral mucositis in adults receiving fluorouracil-based chemotherapy for solid cancers, and for the prevention of severe oral mucositis in adults receiving high-dose melphalan-based chemotherapy before hematopoietic stem cell transplantation (HSCT).

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / therapeutic use
  • Cryotherapy
  • Humans
  • Neoplasms / drug therapy
  • Stomatitis / prevention & control*


  • Antineoplastic Agents