The acute anorexic effect of liraglutide, a GLP-1 receptor agonist, does not require functional leptin receptor, serotonin, and hypothalamic POMC and CART activities in mice

Diabetes Res Clin Pract. 2016 Oct;120:186-9. doi: 10.1016/j.diabres.2016.08.009. Epub 2016 Aug 26.

Abstract

The acute anorexic effect of liraglutide, a GLP-1 receptor agonist, did not require functional leptin receptor, serotonin, and hypothalamic proopiomelanocortin and cocaine amphetamine regulated transcript activities in mice, although decrease in functional hypothalamic orexin activity might be involved in the acute anorexic effect of liraglutide.

Keywords: 5-HT; Food intake; GLP-1 receptor; Liraglutide; Orexin; POMC.

MeSH terms

  • Animals
  • Appetite Depressants / pharmacology*
  • Appetite Depressants / therapeutic use
  • Drug Evaluation, Preclinical
  • Energy Intake / drug effects
  • Glucagon-Like Peptide-1 Receptor / agonists
  • Hypothalamus / metabolism
  • Liraglutide / pharmacology*
  • Liraglutide / therapeutic use
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Nerve Tissue Proteins / metabolism*
  • Pro-Opiomelanocortin / metabolism*
  • Receptors, Leptin / genetics
  • Receptors, Leptin / metabolism*
  • Serotonin / physiology*

Substances

  • Appetite Depressants
  • Glucagon-Like Peptide-1 Receptor
  • Nerve Tissue Proteins
  • Receptors, Leptin
  • cocaine- and amphetamine-regulated transcript protein
  • Serotonin
  • Pro-Opiomelanocortin
  • Liraglutide