The acute anorexic effect of liraglutide, a GLP-1 receptor agonist, does not require functional leptin receptor, serotonin, and hypothalamic POMC and CART activities in mice

Katsunori Nonogaki; Takao Kaji

doi:10.1016/j.diabres.2016.08.009

The acute anorexic effect of liraglutide, a GLP-1 receptor agonist, does not require functional leptin receptor, serotonin, and hypothalamic POMC and CART activities in mice

Diabetes Res Clin Pract. 2016 Oct;120:186-9. doi: 10.1016/j.diabres.2016.08.009. Epub 2016 Aug 26.

Authors

Katsunori Nonogaki¹, Takao Kaji²

Affiliations

¹ Department of Diabetes Technology, Tohoku University Graduate School of Biomedical Engineering, Japan. Electronic address: katsu@trc.med.tohoku.ac.jp.
² Department of Diabetes Technology, Tohoku University Graduate School of Biomedical Engineering, Japan.

PMID: 27585115
DOI: 10.1016/j.diabres.2016.08.009

Abstract

The acute anorexic effect of liraglutide, a GLP-1 receptor agonist, did not require functional leptin receptor, serotonin, and hypothalamic proopiomelanocortin and cocaine amphetamine regulated transcript activities in mice, although decrease in functional hypothalamic orexin activity might be involved in the acute anorexic effect of liraglutide.

Keywords: 5-HT; Food intake; GLP-1 receptor; Liraglutide; Orexin; POMC.

MeSH terms

Animals
Appetite Depressants / pharmacology*
Appetite Depressants / therapeutic use
Drug Evaluation, Preclinical
Energy Intake / drug effects
Glucagon-Like Peptide-1 Receptor / agonists
Hypothalamus / metabolism
Liraglutide / pharmacology*
Liraglutide / therapeutic use
Male
Mice
Mice, Inbred C57BL
Nerve Tissue Proteins / metabolism*
Pro-Opiomelanocortin / metabolism*
Receptors, Leptin / genetics
Receptors, Leptin / metabolism*
Serotonin / physiology*

Substances

Appetite Depressants
Glucagon-Like Peptide-1 Receptor
Nerve Tissue Proteins
Receptors, Leptin
cocaine- and amphetamine-regulated transcript protein
Serotonin
Pro-Opiomelanocortin
Liraglutide