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Review
. 2016 Sep;10(9):1009-22.
doi: 10.2217/bmm-2016-0035. Epub 2016 Sep 2.

Circulating Cell-Derived Microparticles as Biomarkers in Cardiovascular Disease

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Review

Circulating Cell-Derived Microparticles as Biomarkers in Cardiovascular Disease

Åsa Thulin et al. Biomark Med. .

Abstract

Cardiovascular diseases (CVDs) are a common cause of death, and a search for biomarkers for risk stratification is warranted. Elevated levels of cell-derived microparticles (MPs) are found in patients with CVD and in groups with risk factors for CVD. Subpopulations of MPs are promising biomarkers for improving risk prediction, as well as monitoring treatment. However, the field has been hampered by technical difficulties, and the ongoing development of sensitive standardized techniques is crucial for implementing MP analyses in the clinic. Large prospective studies are required to establish which MPs are of prognostic value in different patient groups. In this review, we discuss methodological challenges and progress in the field, as well as MP populations that are of interest for further clinical evaluation.

Keywords: atrial fibrillation; biomarkers; cardiovascular disease; heart failure; microparticles; myocardial infarction; stroke.

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