Effect of Flavonoid-Rich Extract of Glycyrrhiza glabra on Gut-Friendly Microorganisms, Commercial Probiotic Preparations, and Digestive Enzymes

J Diet Suppl. 2017 May 4;14(3):323-333. doi: 10.1080/19390211.2016.1223257. Epub 2016 Sep 2.


Flavonoid-rich extract prepared from Glycyrrhiza glabra has been found to be beneficial in patients with functional dyspepsia and was reported to possess some gut health-promoting properties such as antioxidant, anti-inflammatory and anti-Helicobacter pylori activities. In the present study, the flavonoid-rich extract of Glycyrrhiza glabra was evaluated for its compatibility with probiotic strains (Lactobacillus casei, Lactobacillus fermentum, Lactobacillus plantarum, and Streptococcus thermophilus), commercial probiotic drinks, and digestive enzymes (pancreatic α-amylase, α-glucosidase, phytase, xylanase, and pancreatic lipase). Results of this study indicated that the flavonoid-rich extract of Glycyrrhiza glabra is compatible with the tested probiotic strains, probiotic drinks and digestive enzymes.

Keywords: Glycyrrhiza glabra; digestive enzymes; gut health; probiotics.

MeSH terms

  • 6-Phytase / drug effects
  • Digestion / drug effects*
  • Endo-1,4-beta Xylanases / drug effects
  • Flavonoids / pharmacology*
  • Gastrointestinal Microbiome / drug effects*
  • Glycyrrhiza / chemistry*
  • Humans
  • Lactobacillus / drug effects
  • Lipase / drug effects
  • Pancreatic alpha-Amylases / drug effects
  • Plant Extracts / pharmacology*
  • Probiotics*
  • Solutions
  • alpha-Glucosidases / drug effects


  • Flavonoids
  • Plant Extracts
  • Solutions
  • Lipase
  • 6-Phytase
  • Pancreatic alpha-Amylases
  • alpha-Glucosidases
  • Endo-1,4-beta Xylanases