APOL1-Associated End-Stage Renal Disease in a Living Kidney Transplant Donor

Am J Transplant. 2016 Dec;16(12):3568-3572. doi: 10.1111/ajt.14035. Epub 2016 Oct 6.

Abstract

Homozygosity for apolipoprotein-L1 (APOL1) risk variants has emerged as an important predictor of renal disease in individuals of African descent over the past several years. Additionally, these risk variants may be important predictors of renal allograft failure when present in a living or deceased donor. Currently, there is no universal recommendation for screening of potential donors. We present a case of end-stage renal disease with focal segmental glomerulosclerosis in a living donor 7 years following donor nephrectomy. Genetic assessment revealed homozygosity for the G1 high-risk APOL1 variant.

Keywords: clinical research/practice; donor nephrectomy; donors and donation: donor follow-up; donors and donation: living; kidney transplantation/nephrology; organ transplantation in general; pathology/histopathology.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • African Americans
  • Apolipoprotein L1 / genetics*
  • Biomarkers
  • Female
  • Genetic Variation*
  • Genotype
  • Glomerular Filtration Rate
  • Homozygote
  • Humans
  • Kidney Failure, Chronic / etiology*
  • Kidney Failure, Chronic / metabolism
  • Kidney Failure, Chronic / pathology
  • Kidney Function Tests
  • Kidney Transplantation / adverse effects*
  • Living Donors*
  • Prognosis
  • Risk Factors
  • Tissue and Organ Harvesting

Substances

  • APOL1 protein, human
  • Apolipoprotein L1
  • Biomarkers