Encapsulation of Aloe Vera extract into natural Tragacanth Gum as a novel green wound healing product

Int J Biol Macromol. 2016 Dec;93(Pt A):344-349. doi: 10.1016/j.ijbiomac.2016.08.076. Epub 2016 Aug 30.


Application of natural materials in wound healing is an interest topic due to effective treatment with no side effects. In this paper, Aloe Vera extract was encapsulated into Tragacanth Gum through a sonochemical microemulsion process to prepare a wound healing product. FESEM/EDX and FT-IR proved the successfully formation of the nanocapsules with spherical shape by cross-linking aluminum ions with Tragacanth Gum. The therapeutic characteristics of the prepared wound healing product were investigated using antimicrobial, cytotoxicity and wound healing assays. Relative high antimicrobial activities with the microbial reduction of 84, 91 and 80% against E. coli, S. aureus and C. albicans, a cell viability of 98% against human fibroblast cells and a good wound healing activity with considerable migration rate of fibroblast cells are the important advantages of the new formed wound healing product.

Keywords: Aloe Vera extract; Nanocapsules; Scratch assay; Tragacanth Gum; Wound healing product.

MeSH terms

  • Aloe / chemistry*
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / pharmacology
  • Anti-Infective Agents / toxicity
  • Capsules
  • Cell Line
  • Green Chemistry Technology
  • Humans
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology*
  • Plant Extracts / toxicity
  • Tragacanth / chemistry*
  • Wound Healing / drug effects*


  • Anti-Infective Agents
  • Capsules
  • Plant Extracts
  • Tragacanth