Liposarcoma: Multimodality Management and Future Targeted Therapies

Surg Oncol Clin N Am. 2016 Oct;25(4):761-73. doi: 10.1016/j.soc.2016.05.007. Epub 2016 Jul 30.


There are 3 biologic groups of liposarcoma: well-differentiated and dedifferentiated liposarcoma, myxoid/round cell liposarcoma, and pleomorphic liposarcoma. In all 3 groups, complete surgical resection is central in treatment aimed at cure and is based on grade. Radiation can reduce risk of local recurrence in high-grade lesions or minimize surgical morbidity in the myxoid/round cell liposarcoma group. The groups differ in chemosensitivity, so adjuvant chemotherapy is selectively used in histologies with metastatic potential but not in the resistant subtype dedifferentiated liposarcoma. Improved understanding of the genetic aberrations that lead to liposarcoma initiation is allowing for the rapid development of targeted therapies for liposarcoma.

Keywords: CDK4; FUS-CHOP; Liposarcoma; MDM2; Myxoid liposarcoma; Pleomorphic liposarcoma; Sarcoma; Trabectedin.

Publication types

  • Review

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Humans
  • Liposarcoma / classification*
  • Liposarcoma / pathology
  • Liposarcoma / therapy*
  • Liposarcoma, Myxoid / pathology
  • Liposarcoma, Myxoid / therapy*
  • Molecular Targeted Therapy*
  • Multimodal Imaging
  • Neoplasm Grading
  • Neoplasm Recurrence, Local
  • Precision Medicine