PC12 pheochromocytoma and sympathetic nervous system derived trophic factors augment growth of neuroblastoma

E Chelmicka-Schorr; M E Checinski; B G Arnason

doi:10.1016/0277-5379(89)90388-x

PC12 pheochromocytoma and sympathetic nervous system derived trophic factors augment growth of neuroblastoma

Eur J Cancer Clin Oncol. 1989 Jul;25(7):1057-9. doi: 10.1016/0277-5379(89)90388-x.

Authors

E Chelmicka-Schorr¹, M E Checinski, B G Arnason

Affiliation

¹ Department of Neurology, University of Chicago, IL 60637.

PMID: 2759161
DOI: 10.1016/0277-5379(89)90388-x

Abstract

A trophic factor secreted by PC12 rat pheochromocytoma augments growth of C1300 neuroblastoma clonal lines S20, N18 and C46, but does not affect growth of the NIE 115 line. A trophic factor present in newborn sympathetic ganglia has the same biological effect on neuroblastoma cell lines. PC12 cells and sympathetic ganglia are both of neural crest origin; possibly both secrete the same trophic factor.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Adrenal Gland Neoplasms / metabolism
Animals
Ganglia, Sympathetic / metabolism*
Mice
Nerve Growth Factors / physiology*
Nerve Tissue Proteins / physiology*
Neuroblastoma / pathology*
Pheochromocytoma / metabolism*
Rats
Rats, Inbred WF
Tumor Cells, Cultured / metabolism

Substances

Nerve Growth Factors
Nerve Tissue Proteins

Grants and funding

NS-18413/NS/NINDS NIH HHS/United States