PC12 pheochromocytoma and sympathetic nervous system derived trophic factors augment growth of neuroblastoma

Eur J Cancer Clin Oncol. 1989 Jul;25(7):1057-9. doi: 10.1016/0277-5379(89)90388-x.


A trophic factor secreted by PC12 rat pheochromocytoma augments growth of C1300 neuroblastoma clonal lines S20, N18 and C46, but does not affect growth of the NIE 115 line. A trophic factor present in newborn sympathetic ganglia has the same biological effect on neuroblastoma cell lines. PC12 cells and sympathetic ganglia are both of neural crest origin; possibly both secrete the same trophic factor.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adrenal Gland Neoplasms / metabolism
  • Animals
  • Ganglia, Sympathetic / metabolism*
  • Mice
  • Nerve Growth Factors / physiology*
  • Nerve Tissue Proteins / physiology*
  • Neuroblastoma / pathology*
  • Pheochromocytoma / metabolism*
  • Rats
  • Rats, Inbred WF
  • Tumor Cells, Cultured / metabolism


  • Nerve Growth Factors
  • Nerve Tissue Proteins