Oxidative stress parameters in localized scleroderma patients

Arch Dermatol Res. 2016 Nov;308(9):625-629. doi: 10.1007/s00403-016-1682-3. Epub 2016 Sep 3.

Abstract

Localized scleroderma (LS) (morphea) is a chronic, inflammatory skin disease with unknown cause that progresses with sclerosis in the skin and/or subcutaneous tissues. Its pathogenesis is not completely understood. Oxidative stress is suggested to have a role in the pathogenesis of localized scleroderma. We have aimed to determine the relationship of morphea lesions with oxidative stress. The total oxidant capacity (TOC), total antioxidant capacity (TAC), paroxonase (PON) and arylesterase (ARES) activity parameters of PON 1 enzyme levels in the serum were investigated in 13 LS patients (generalized and plaque type) and 13 healthy controls. TOC values of the patient group were found higher than the TOC values of the control group (p < 0.01). ARES values of the patient group was found to be higher than the control group (p < 0.0001). OSI was significantly higher in the patient group when compared to the control (p < 0.005). Oxidative stress seems to be effective in the pathogenesis. ARES levels have increased in morphea patients regarding to the oxidative stress and its reduction. Further controlled studies are required in wider series.

Keywords: Arylesterase; Localized scleroderma; Oxidative stress.

MeSH terms

  • Adult
  • Aged
  • Antioxidants / analysis*
  • Aryldialkylphosphatase / blood*
  • Carboxylic Ester Hydrolases / blood*
  • Female
  • Healthy Volunteers
  • Humans
  • Male
  • Middle Aged
  • Oxidative Stress*
  • Scleroderma, Localized / blood
  • Scleroderma, Localized / metabolism*
  • Scleroderma, Localized / physiopathology*
  • Young Adult

Substances

  • Antioxidants
  • Carboxylic Ester Hydrolases
  • arylesterase
  • Aryldialkylphosphatase
  • PON1 protein, human