Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[ 18 F]fluoro-D-glucose positron emission and computed tomography

Nat Med. 2016 Oct;22(10):1090-1093. doi: 10.1038/nm.4161. Epub 2016 Sep 5.

Abstract

Tuberculosis is classically divided into states of latent infection and active disease. Using combined positron emission and computed tomography in 35 asymptomatic, antiretroviral-therapy-naive, HIV-1-infected adults with latent tuberculosis, we identified ten individuals with pulmonary abnormalities suggestive of subclinical, active disease who were substantially more likely to progress to clinical disease. Our findings challenge the conventional two-state paradigm and may aid future identification of biomarkers that are predictive of progression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural

MeSH terms

  • Adult
  • Coinfection / diagnostic imaging
  • Disease Progression
  • Female
  • Fluorodeoxyglucose F18
  • HIV Infections / complications*
  • Humans
  • Interferon-gamma Release Tests
  • Latent Tuberculosis / complications
  • Latent Tuberculosis / diagnostic imaging*
  • Male
  • Mycobacterium tuberculosis / isolation & purification
  • Positron Emission Tomography Computed Tomography
  • Radiography, Thoracic
  • Radiopharmaceuticals
  • South Africa
  • Sputum / microbiology
  • Tuberculosis / complications
  • Tuberculosis / diagnostic imaging
  • Tuberculosis, Pulmonary / complications
  • Tuberculosis, Pulmonary / diagnostic imaging*

Substances

  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18